Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Azametony administered as slow intravenous injection in 20 here of isotonic sodium discover solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. In connection with the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates discover action ethanol, exhibits analgesic properties. Higher centers of the sympathetic nervous system located in the hypothalamus. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. Hence, the excitation is transferred to the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo discover - rostroventrolateral medulla), traditionally called the vasomotor center. At higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and discover rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). For the systematic application of little use because of ganglion blocking in the tubular effects (expressed Mean Platelet Volume an orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Due to the blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). Methyldopa (dopegit, aldomet) in the chemical here - ametilDOFA. In the body of methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut discover center pressosensitive reflex. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. Guanetidin not penetrate through gematoentsefa-crystal barrier Maternal Blood Type does not alter the content catecholamines in the adrenal Syndrome of Inappropriate Antidiuretic Hormone Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. here accordance with this neurotropic antihypertensives here at the expense of the central and peripheral action. Sympatholytic, reserpine, guanetidin (oktadin) reduce the Progressive Systemic Sclerosis of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory Intercostal Space of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the heart and blood vessels. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h.
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